Milly (Collette) is the woman who has everything. Her best friend Jess (Barrymore) works in a community garden, lives in a boathouse and desperately wants a baby. Friends since childhood Jess and Milly can't remember a time they didn't share everything - secrets, clothes, even boyfriends, their differences are the glue that binds them together. That is until Milly is hit with the life changing news that she has breast cancer and now needs Jess to be the strong one.