D.W. Thinks Big

Bruce Dinsmore

Mr. Read / Binky Barnes / Bailey (voice)

Jodie Resther

Francine Frensky (voice)

Daniel Brochu

Buster Baxter (voice)

Melissa Altro

Muffy Crosswire (voice)

Tracy Braunstein

Baby Kate (voice)

Simon Peacock

Pal (voice)

Luke Reid

Alan "The Brain" Powers (voice)

Joanna Noyes

Grandma Thora (voice)

Tamar Kozlov

Prunella (voice)

Mitchell David Rothpan

George (voice)

Michael Yarmush

Arthur Read (voice)

Patricia Rodríguez

Sue Ellen Armstrong (voice)

Jonathan Koensgen

Tommy Tibble (voice)

Ricky Mabe

Timmy Tibble (voice)

A.J. Henderson

Grandpa Dave (voice)

Michael Caloz

Cora (voice)

Sonja Ball

Lucy (voice)

Susan Glover

Aunt Jessica (voice)

Arthur Holden

Uncle Richard (voice)