In this TV production, a male and female duo, who know absolutely nothing about each other, are forced to cohabit for 21 days in a harsh environment, in the most isolated regions of the planet, with no water, no food and... no clothes! Each week, a pair is challenged to survive against adverse climatic conditions and the threat of dangerous predators. Abandoned in these isolated places, with only a few basic tools, they must find solutions to feed, clothe and shelter themselves. However, the two main players will first have to get to know each other and learn to establish a relationship of trust if they are to survive. A medical team observes their development and reports on their progress, or difficulties, with the aim of succeeding.