How Roundup Kills Weeds (And How Weeds are Fighting Back)

In 1997 there were 432 new patents for herbicides, by 2009 there were only 65. The development of broad spectrum glyphosate and “Roundup Ready crops” was a game changer that worked so well people basically stopped looking for new herbicides. That is until the weeds started fighting back.

Chemical & Engineering News article on the search for new modes of action
https://cen.acs.org/environment/pesticides/crop-protection-herbicide-mode-action-glyphosate/100/i22

Introduction to the Shikimate Pathway
https://www.youtube.com/watch?v=FlBrJW-qbXA&list=PL833687AEAAE90961&index=155


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Credits:
Executive Producer:
Matthew Radcliff

Producers:
Elaine Seward
Andrew Sobey
Darren Weaver

Host:
Alex Dainis

Scientific Consultants:
Mark Loux, PhD
Patrick J. Tranel, PhD
Todd Gaines, PhD
Mithila Jugulam, Ph.D.
Leila Duman, PhD
Brianne Raccor, PhD

Executive in Charge for PBS: Maribel Lopez
Director of Programming for PBS: Gabrielle Ewing
Assistant Director of Programming for PBS: John Campbell


Reactions is a production of the American Chemical Society.
© 2022 American Chemical Society. All rights reserved.


Additional Sources:
Molecular basis for the herbicide resistance of Roundup Ready crops
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559744/

THE SHIKIMATE PATHWAY
https://www.annualreviews.org/doi/10.1146/annurev.arplant.50.1.473

Why have no new herbicide modes of action appeared in recent years?
https://onlinelibrary.wiley.com/doi/10.1002/ps.2333

The Pitfalls of Relating Weeds, Herbicide Use, and Crop Yield: Don't Fall Into the Trap! A Critical Review
https://www.frontiersin.org/articles/10.3389/fagro.2020.615470/full

The cost of herbicide resistance
https://crops.extension.iastate.edu/blog/bob-hartzler/cost-herbicide-resistance

Development and Characterization of a CP4 EPSPS-Based, Glyphosate-Tolerant Corn Event
https://web.archive.org/web/20090319094255/http://crop.scijournals.org/cgi/content/abstract/45/1/329?ijkey=44fad6f377d5b5dfe274484eb51a4c79d0d7ff63&keytype2=tf_ipsecsha

Tyrosine Biosynthesis, Metabolism, and Catabolism in Plants
https://bit.ly/3CsMiiS

Biosynthesis and Metabolic Fate of Phenylalanine in Conifers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942462/

Auxin driven indoleamine biosynthesis and the role of tryptophan as an inductive signal in Hypericum perforatum (L.)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797091/

Finding of No Significant Impact
Animal and Plant Health Inspection Service
Petition for Non-regulated Status for Soybean Line MON 89788 (APHIS 06-178-01p)
https://www.aphis.usda.gov/brs/aphisdocs/06_17801p_ea.pdf

Glyphosate resistance: state of knowledge
https://onlinelibrary.wiley.com/doi/pdf/10.1002/ps.3743

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