A temporada 2 de Doc Martin foi transmitida em ITV1 de jeudi 10 novembre 2005 para lundi 25 décembre 2006. Consiste em 9 episódios, o primeiro chama-se "Old Dogs" e o último "On the Edge"..
Make an appointment with the brilliant but socially awkward and neurotic Doc Martin. When Martin develops an aversion to blood, he abandons his career as a celebrated London surgeon and becomes the only doctor in a sleepy small town where his tactless manner soon has the whole town in an uproar.