The Shame Wizard

Nick Kroll

Nick Birch / Maury the Hormone Monster / Coach Steve / Lola Skumpy / Rick the Hormone Monster (voice)

John Mulaney

Andrew Glouberman (voice)

Jessi Klein

Jessi Glaser (voice)

Jenny Slate

Missy Foreman-Greenwald (voice)

Jason Mantzoukas

Jay Bilzerian (voice)

Maya Rudolph

Diane Birch / Connie the Hormone Monstress (voice)

Fred Armisen

Elliot Birch (voice)

Jordan Peele

Ghost of Duke Ellington (voice)

Jessica Chaffin

Shannon Glaser (voice)

Jak Knight

DeVon / Gina's Brother #2 (voice)

Ashley London

The Virgin Mary / Waitress (voice)

Philip Quinaz

Tanya Alvarez (voice)

Zach Woods

Sock (voice)

Joe Wengert

Caleb (voice)

David Thewlis

Shame Wizard (voice)

Heather Lawless

Jenna Bilzerian (voice)

Kat Dennings

Leah Birch (voice)

Paula Pell

Barbara Glouberman (voice)

Gina Rodriguez

Gina Alvarez (voice)

Seth Morris

Greg Glaser (voice)

Richard Kind

Marty Glouberman (voice)