La temporada 2 de Safe House 2021 se emitió en GMM25 de lundi 15 novembre 2021 a dimanche 21 novembre 2021. Consta de 19 episodios, el primero se llama "Safe House Live | Winter Camp Day 1" y el último "Day 7"..
Safe House follows the lives of eight GMMTV artists morning to night as they live under one roof and compete to win a grand prize.