Ozzy & Drix

Phil LaMarr

Osmosis Jones (voice)

Jeff Bennett

Drix (voice)

Alanna Ubach

Mayor Paul Spryman / Hector's Mom (voice)

Justin Cowden

Hector Cruz (voice)

Tasia Valenza

Maria Amino (voice)

Jim Cummings

Police Chief Gluteus (voice)

Rob Paulsen

Backseat / Travis Lum (voice) / Stickety Lipid (voice) / Travis Lum (voice)

Vivica A. Fox

Ellen Patella (voice)

Pat Fraley

Brain Advisor #1 (voice) / Nerve Cell General (voice) / Pnuemoniac (voice)

Frank Welker

Billy Blob Bile (voice) / Dander (voice) / Tar (voice)

Charlie Adler

Abglobtus Goop (voice) / General Malaise (voice) / General Malaise / Dr. Hammertoe (voice)

Jeffrey Tambor

The Mole (voice)

Kimberly Brooks

Christine Kolchuck (voice)

Kevin Michael Richardson

Rescue Cell (voice)

Cree Summer

Mayor Santorini (voice)

Tim Curry

Nick O'Teen (voice) / Scarlet Fever (voice)

Tara Strong

Ashley / Carbon Monoxide (voice) / Jenna (voice)

Brad Garrett

Strepfinger (voice)

Dawnn Lewis

Cilia Tyson (voice)

Joe Lala

Hector's Dad (voice)

Jim Belushi

Captain Quinine (voice)

Kath Soucie

Naurine / Celly Katz (voice)

Andrea Martin

Aunti Histamine (voice)

Candi Milo

Mumsy Glop (voice)

Miriam Flynn

Drixeen (voice)

Neil Ross

Cop (voice)

Justine Bateman

Rota (voice)

Billy West

Muscle Cell (voice)

Danny Bonaduce

Smirch (voice)

April Winchell

Cafeteria Lady (voice)

Wendie Malick

Number 2 / Sticky Flagella (voice)

Jess Harnell

Shwee (voice)

Julian Sands

Penicillin G (voice)

Rino Romano

Jude (voice)

Danny Mann

Rudy (voice)

Roger Rose

Jumbo (voice)

Henry Winkler

Sal Monella (voice)

Brian Posehn

Sylvian Fisher (voice)

Kathy Najimy

Loretta Epstein (voice)

Danny Cooksey

Shane (voice)

Hope Levy

Brittany Estrogen (voice)

Jeffrey Garcia

Ricardo Amino (voice)

Dee Bradley Baker

Father Glop (voice)

Susan Silo

Cryo (voice)