CatDog

Jim Cummings

Cat (voice)

Tom Kenny

Dog (voice) / Dog / Cliff (voice)

Carlos Alazraqui

Winslow (voice) / Winslow / Lube (voice)

Maria Bamford

Shriek (voice)

Billy West

Rancid Rabbit (voice)

Dwight Schultz

Eddie the Squirrel (voice) / Eddy (voice)

Nika Futterman

Lola (voice)

John Kassir

Dunglap / Mervis (voice)

Laraine Newman

The Ingrid Twins (voice) / The Ingrid Twins / Boy in Crowd (voice)

Brian Doyle-Murray

Santa Claus

Jane Krakowski

CatDog's Mother (voice) / Mother (voice)

Billy Bob Thornton

CatDog's Father (voice) / Father (voice)

Frank Welker

Bessie the Sea Monster (voice)

Greg Burson

Barry the Baboon (voice)

Dave Thomas

Mean Bob (voice)

Rodger Bumpass

Pig / Man (voice)

April Winchell

Space Grannies (voice)

Peter Hannan

Pete the Polecat (voice)