Samantha Who?

Christina Applegate

Samantha Newly

Jennifer Esposito

Andrea Belladonna

Kevin Dunn

Howard

Melissa McCarthy

Dena

Tim Russ

Frank

Barry Watson

Todd

Jean Smart

Regina Newly

Rick Hoffman

Chase Chapman

Stephen Rannazzisi

Seth

Billy Zane

Winston Funk

Kiele Sanchez

Chloe

James Tupper

Owen

Joy Osmanski

Tracy

McKinley Freeman

Tony Dane

Eliza Coupe

Willow

Eddie Cibrian

Kevin

Dana Sorman

Jerri

Adam Devine

Tyler

Nakia Burrise

Kerry Hall

Timothy Olyphant

Winston Funk

Natasha Leggero

Woman Customer

Anthony Anderson

Rafael Grace

Mark Ballas

Mateo Romero

Tony Hale

Andy Adams

Teddy Sears

Brad

Rebecca Wisocky

Lindsey

Brett Rickaby

AA Leader

Beth Littleford

Audrey Rhodes

Ryan Carnes

Brent

Cybill Shepherd

Paula Drake

Mary-Kate Olsen

Natalie

James Patrick Stuart

Bill Jacobs

Andre Ware

Mac Fresh

Jerry O'Connell

Craig

Miranda May

13-Year-Old Dena

William Abadie

Rene

Jelynn Sophia

Angry Woman

Dan Thiel

Dave

Adam Jennings

Barista

Jill Talley

AA Female Leader

Frank Maharajh

Dr. Kegoshian

Jamison Haase

Vic

B.J. Clinkscales

Waiter

Jessica St. Clair

Valerie

Gerald Downey

Paul

Curt Cornelius

Trey

Amanda Young

Paul's Wife

Kara Taitz

Bridesmaid

Ryan Carlberg

Jason

Rand Holdren

Ryan

Sarah Spiegel

Young Woman

Todd Grinnell

Nathan

Johanna Braddy

Teenage Samantha

Jagger Chase

Kid

Kelsey Lee Smith

Young Samantha

Marilyn Sue Perry

Cashier

Arshad Aslam

Barista

Reggie Jordan

Flower Delivery Guy

Timon Kyle Durrett

Russ

Tanya Bond

Girl

Ossie Mair

Driver

Jaclyn Kerhulas

Sign Language Interpreter

Morgan Murphy

Woman Protestor

Jim Rash

Artist

Jonathan Schmock

Hipster

Brandon Ford Green

Guy

Ian Duncan

Cameron

Soledad Campos

Woman

Tony Winters

Man

Melody Butiu

Nurse

Brian Catalano

Orderly

Sarah Rafferty

Kayla Kaminski

Gregory Franklin

Announcer

Rachel Cannon

Carol

Phoebe Dorin

Older Woman

Brian D. Phelan

Cute Guy

William Borger

Crying Kid

Roxana Ortega

Allison

Steve Wilson

Foreman

Carla Greene

Waitress

Annette M. Lesure

Waitress

Sayeed Shahidi

Little Boy

Marsh Mokhtari

Mike

Joni Kempner

Cameron

Cooper Thornton

Instructor

David Douglas

Barista

Mary Alyce Kania

Waitress

Barry Finkel

Funeral Director

Laurie Okin

Mother

Stefan Marks

Detective Harp

Ty Barnett

Mugger

Karlton Johnson

Policeman

Tara Ochs

Waitress

Michael Crider

Roth

Ken Rudulph

Reporter

Brent Tarnol

Jason

John Taylor

Tommy Wylder

Greg Cipes

Street Musician

Terryn Westbrook

Female Fan #1

Kathryn Taylor Smith

Female Fan #2

Susie Geiser

Woman

Amanda Collier

13-Year-Old Samantha

Dondré Whitfield

Wes Green

Robin Gwynne

Wife

Christine Ebersole

Amy

Florence Henderson

Loretta

Nora Dunn

Cheryl

Hahn Cho

Doctor

Terrance Christopher Jones

Teacher

Abdoulaye N'Gom

Minister

Denise Gossett

Homeless Woman

Indira G. Wilson

Photographer

Charles C. Stevenson Jr.

Gentleman

Angie Harmon

Gigi

Bree Condon

Mickey

Jackie Johnson

Jackie Johnson

Shulie Cowen

Dolly

Greg Callahan

Fake Dad

David Trice

Baggage Service Rep

Anna Zielinski

Ticket Agent

Andre M. Johnson

Security Guard

J.P. Gillain

Philippe

Larry Reitzer

Duncan Weber

Tony Jones

Police Sergeant