Forever Chemicals

Forever chemicals are used in everything from rain jackets to jet fuel. But the chemistry behind what makes them useful also makes them stick around in the environment and us...forever?

#pfas #foreverchemicals #pfoa #genx #pfos

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Credits:
Executive Producers:
George Zaidan
Hilary Hudson

Producers:
Andrew Sobey
Elaine Seward

Writer/Host:
Sam Jones, PhD

Scientific consultants:
David Andrews, PhD
Jamie DeWitt, PhD
Leila Duman, PhD
Cheryl Hogue
Brianne Raccor, PhD

Sources:
First study on PFAS binding to human serum
https://www.jbc.org/article/S0021-9258(18)65805-3/pdf

PFAS Half-Life
https://www.nrdc.org/sites/default/files/media-uploads/nrdc_pfas_report.pdf

Albumin is the major carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in human plasma
https://www.sciencedirect.com/science/article/pii/S0160412019331964

PFAS in the environment
https://www.tn.gov/content/dam/tn/environment/solid-waste/documents/esos/sw_esos-13_2018-05-16-1540-jones.pdf

An overview of the uses of per- and polyfluoroalkyl substances (PFAS)
https://pubs.rsc.org/en/content/articlelanding/2020/em/d0em00291g#!divAbstract

Understanding organofluorine chemistry. An introduction to the C–F bond
https://pubs.rsc.org/en/content/articlelanding/2008/cs/b711844a/unauth#!divAbstract

EPA Takes Action to Address PFAS in Drinking Water
https://www.epa.gov/newsreleases/epa-takes-action-address-pfas-drinking-water

The hunt is on for GenX chemicals in people
https://cen.acs.org/environment/persistent-pollutants/hunt-GenX-chemicals-people/97/i14

Scientific Basis for Managing PFAS as a Chemical Class
https://pubs.acs.org/doi/10.1021/acs.estlett.0c00255


A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects
https://pubmed.ncbi.nlm.nih.gov/30470793/

‘Forever chemicals’ no more? These technologies aim to destroy PFAS in water
https://cen.acs.org/environment/persistent-pollutants/Forever-chemicals-technologies-aim-destroy/97/i12

Deposition of PFAS 'forever chemicals' on Mt. Everest
https://pubmed.ncbi.nlm.nih.gov/33353778/

A review of the emerging treatment technologies for PFAS contaminated soils
https://pubmed.ncbi.nlm.nih.gov/32063301/

Human exposure to per- and polyfluoroalkyl substances (PFAS) through drinking water: A review of the recent scientific literature
https://pubmed.ncbi.nlm.nih.gov/31421451/

PFAS guide
https://cen.acs.org/sections/pfas.html

PFAS Research
https://www.niehs.nih.gov/research/programs/pfas/index.cfm

Endocrine Disruption of Androgenic Activity by Perfluoroalkyl Substances: Clinical and Experimental Evidence
https://academic.oup.com/jcem/article/104/4/1259/5158211

EPA Action Plan (2019)
https://www.epa.gov/sites/production/files/2019-02/documents/pfas_action_plan_021319_508compliant_1.pdf

PFAS FDA
https://www.fda.gov/food/chemicals/and-polyfluoroalkyl-substances-pfas

Contamination map in US
https://www.ewg.org/interactive-maps/pfas_contamination/map/

Accumulation of perfluoroalkyl substances in human tissues
https://www.sciencedirect.com/science/article/pii/S0160412013001220

High Levels Of ‘Forever Chemicals’ Detected In Northern Virginia Drinking Water
https://dcist.com/story/21/03/10/high-levels-toxic-pfas-forever-chemicals-northern-virginia-drinking-water/

PFAS fact sheet
https://www.ngwa.org/docs/default-source/default-document-library/pfas/pfastop-10.pdf?sfvrsn=8c8ef98b_2#:~:text=Studies%20have%20estimated%2095%20percent,%2C%20inhalation%2C%20and%20occupational%20contact.

Accumulation of perfluoroalkyl substances in human tissues
https://www.sciencedirect.com/science/article/pii/S0160412013001220?via%3Dihub

Binding of PFOS to serum albumin and DNA: insight into the molecular toxicity of perfluorochemicals
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656506/

How to say goodbye to PFAS
https://cen.acs.org/environment/persistent-pollutants/say-goodbye-PFAS/97/i46

Viscous Microemulsions of Aqueous Film-Forming Foam (AFFF) and Jet Fuel A Inhibit Infiltration and Subsurface Transport
https://pubs.acs.org/doi/10.1021/acs.estlett.0c00868


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