Säsongen 2 av Frasier sändes på NBC från mardi 20 septembre 1994 till jeudi 1 janvier 1970. Den består av 32 avsnitt, det första heter "Slow Tango in South Seattle" och det sista "The Niles & Daphne Attraction"..
After many years spent at the "Cheers" bar, Frasier moves back home to Seattle after his policeman father Martin Crane gets shot in the hip on duty. After Martin struggles with living alone after the incident, he moves in with Frasier in his luxury apartment at the Elliot Bay Towers along with his dog Eddie. Hired by Frasier, Daphne Moon also moves in as Martin's personal physiotherapist. Also living nearby is his younger brother Niles Crane, who is also a Psychiatrist.