Säsongen 2 av Route 66 sändes på CBS från vendredi 22 septembre 1961 till vendredi 1 juin 1962. Den består av 32 avsnitt, det första heter "A Month of Sundays" och det sista "From an Enchantress Fleeing"..
Tod, from a once-wealthy family, inherited only a Corvette when his father died, so he and Buz (suddenly jobless because he worked for Tod's father's company) strike out across North America, especially along the iconic Route 66 from Chicago to L.A. which the Okies traveled. Tod and Buz take local jobs (such as shrimping, shipbuilding, oil rigging) to support their wanderings. The 2 socially conscious knights of the road, encourage, champion, and learn from oppressed and troubled people they encounter. (Written by David Stevens)