La saison 2 de Live at the Apollo a été diffusée sur BBC Two du lundi 12 septembre 2005 au lundi 17 octobre 2005. Elle comporte 6 épisodes, le premier s'intitule "Jack Dee, Lee Mack" et le dernier "Jack Dee, Julian Clary".
At the forefront of its genre, the roll-call of stand-ups who have performed in front of the famous Live At The Apollo lights plays out like a who's who of comedic royalty. Each episode sees a national (and sometimes international) stand-up both compering and performing, before introducing two of the best established and up-coming stand-ups to the stage.