Ghost on the Highway

Sam and Dean were traveling in the Impala in the suburbs of New Orleans, when suddenly a police car starts chasing them. They are accused of being involved in a hit-and-run accident and causing a rear-end collision. The police arrest them without listening to their side of the story, but they are saved by Michael, the police chief's little brother and the vice-police chief, and are able to escape from the jail. However, hearing Michael mutter "the criminal might not be a human" piques their interest, so they decide to get in touch with him, but...

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S01E05 - Savage Blood